The SOPHIA project (Stratification of Obesity Phenotypes to Optimise Future Obesity Therapy) is a Public-Private Partnership funded by the Innovative Health Initiative (IMI) in collaboration with the European Commission, and is part of a momentum shift in the study of obesity. This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875534. The JU receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA and T1D Exchange, JDRF, and Obesity Action Coalition.